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anti rad21  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc anti rad21
    Anti Rad21, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 38 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti rad21/product/Cell Signaling Technology Inc
    Average 94 stars, based on 38 article reviews
    anti rad21 - by Bioz Stars, 2026-02
    94/100 stars

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    ( A ) MA plot showing changes in chromatin accessibility following 12 h of treatment with 100 nM largazole. Genomic sites exhibiting statistically significant changes ( padjust < 0.05), determined through DESeq2 analysis 56 , are highlighted in orange, with those located within super-enhancer regions indicated in red. ( B ) ChromHMM heatmap depicting an 11-state chromatin roadmap of HCT116 cells, generated using data from nascent RNA, seven histone modifications (H3K36me3, H3K27ac, H3K9ac, H3K4me3, H3K4me1, H4K20me3, and H3K27me3), and three chromatin interactors (BRD4, <t>RAD21,</t> and CTCF). The intensity of the red color reflects the probability of observing the respective mark in each state. Candidate-state descriptions and corresponding color codes are shown to the right. The adjacent bar graph illustrates the genomic distribution of ATAC-seq peaks significantly altered by largazole: peaks with reduced accessibility appear on the left, and those with increased accessibility appear on the right. ( C , D ) Genome browser snapshots of the CDKN1A locus ( C ) and the most upstream MYC super-enhancer ( D ) depicting ATAC-seq signal in HCT116 cells treated with either 100 nM largazole or vehicle (DMSO) for 12 h.
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    ( A ) MA plot showing changes in chromatin accessibility following 12 h of treatment with 100 nM largazole. Genomic sites exhibiting statistically significant changes ( padjust < 0.05), determined through DESeq2 analysis 56 , are highlighted in orange, with those located within super-enhancer regions indicated in red. ( B ) ChromHMM heatmap depicting an 11-state chromatin roadmap of HCT116 cells, generated using data from nascent RNA, seven histone modifications (H3K36me3, H3K27ac, H3K9ac, H3K4me3, H3K4me1, H4K20me3, and H3K27me3), and three chromatin interactors (BRD4, <t>RAD21,</t> and CTCF). The intensity of the red color reflects the probability of observing the respective mark in each state. Candidate-state descriptions and corresponding color codes are shown to the right. The adjacent bar graph illustrates the genomic distribution of ATAC-seq peaks significantly altered by largazole: peaks with reduced accessibility appear on the left, and those with increased accessibility appear on the right. ( C , D ) Genome browser snapshots of the CDKN1A locus ( C ) and the most upstream MYC super-enhancer ( D ) depicting ATAC-seq signal in HCT116 cells treated with either 100 nM largazole or vehicle (DMSO) for 12 h.
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    ( A ) MA plot showing changes in chromatin accessibility following 12 h of treatment with 100 nM largazole. Genomic sites exhibiting statistically significant changes ( padjust < 0.05), determined through DESeq2 analysis 56 , are highlighted in orange, with those located within super-enhancer regions indicated in red. ( B ) ChromHMM heatmap depicting an 11-state chromatin roadmap of HCT116 cells, generated using data from nascent RNA, seven histone modifications (H3K36me3, H3K27ac, H3K9ac, H3K4me3, H3K4me1, H4K20me3, and H3K27me3), and three chromatin interactors (BRD4, <t>RAD21,</t> and CTCF). The intensity of the red color reflects the probability of observing the respective mark in each state. Candidate-state descriptions and corresponding color codes are shown to the right. The adjacent bar graph illustrates the genomic distribution of ATAC-seq peaks significantly altered by largazole: peaks with reduced accessibility appear on the left, and those with increased accessibility appear on the right. ( C , D ) Genome browser snapshots of the CDKN1A locus ( C ) and the most upstream MYC super-enhancer ( D ) depicting ATAC-seq signal in HCT116 cells treated with either 100 nM largazole or vehicle (DMSO) for 12 h.
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    Image Search Results


    ( A ) MA plot showing changes in chromatin accessibility following 12 h of treatment with 100 nM largazole. Genomic sites exhibiting statistically significant changes ( padjust < 0.05), determined through DESeq2 analysis 56 , are highlighted in orange, with those located within super-enhancer regions indicated in red. ( B ) ChromHMM heatmap depicting an 11-state chromatin roadmap of HCT116 cells, generated using data from nascent RNA, seven histone modifications (H3K36me3, H3K27ac, H3K9ac, H3K4me3, H3K4me1, H4K20me3, and H3K27me3), and three chromatin interactors (BRD4, RAD21, and CTCF). The intensity of the red color reflects the probability of observing the respective mark in each state. Candidate-state descriptions and corresponding color codes are shown to the right. The adjacent bar graph illustrates the genomic distribution of ATAC-seq peaks significantly altered by largazole: peaks with reduced accessibility appear on the left, and those with increased accessibility appear on the right. ( C , D ) Genome browser snapshots of the CDKN1A locus ( C ) and the most upstream MYC super-enhancer ( D ) depicting ATAC-seq signal in HCT116 cells treated with either 100 nM largazole or vehicle (DMSO) for 12 h.

    Journal: bioRxiv

    Article Title: Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4

    doi: 10.1101/2025.01.29.635612

    Figure Lengend Snippet: ( A ) MA plot showing changes in chromatin accessibility following 12 h of treatment with 100 nM largazole. Genomic sites exhibiting statistically significant changes ( padjust < 0.05), determined through DESeq2 analysis 56 , are highlighted in orange, with those located within super-enhancer regions indicated in red. ( B ) ChromHMM heatmap depicting an 11-state chromatin roadmap of HCT116 cells, generated using data from nascent RNA, seven histone modifications (H3K36me3, H3K27ac, H3K9ac, H3K4me3, H3K4me1, H4K20me3, and H3K27me3), and three chromatin interactors (BRD4, RAD21, and CTCF). The intensity of the red color reflects the probability of observing the respective mark in each state. Candidate-state descriptions and corresponding color codes are shown to the right. The adjacent bar graph illustrates the genomic distribution of ATAC-seq peaks significantly altered by largazole: peaks with reduced accessibility appear on the left, and those with increased accessibility appear on the right. ( C , D ) Genome browser snapshots of the CDKN1A locus ( C ) and the most upstream MYC super-enhancer ( D ) depicting ATAC-seq signal in HCT116 cells treated with either 100 nM largazole or vehicle (DMSO) for 12 h.

    Article Snippet: Signal for all immunoblots was acquired using the ImageQuant LAS 4000 biomolecular imager (GE Healthcare LS) with an average exposure of 30 s. Antibodies used are as follows: SP1 (Santa Cruz Biotechnology, sc-17824); SP4 (Santa Cruz Biotechnology, sc-390124); RAD21 (Cell Signaling, cat. # 4321); STAG2 (Cell Signaling, cat. # 5882); beta-Actin (SC-47778).

    Techniques: Generated